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Harvard University: Unraveling the mysteries of aging

A research team led by David Sinclair at Harvard have made a discovery that could lead to a revolutionary drug that actually reverses aging, improves DNA repair and could even help NASA get its astronauts to Mars. The treatment with the NAD precursor NMN mitigates age-related DNA damage in mice and averts DNA damage from radiation exposure.

The paper A conserved NAD binding pocket that regulates protein-protein interactions during aging was published in Science today, the team identifies a critical step in the molecular process that allows cells to repair damaged DNA.

Professor Sinclair made a link between the anti-ageing enzyme SIRT1 and resveratrol in 2003, this is a naturally occurring molecule found in tiny quantities in red wine. But while resveratrol activates SIRT1 alone, NAD+ boosters activate all seven sirtuins, SIRT1-7, and should have an even greater impact on health and longevity.